Topic 38: Research (Phần 2)

Commentary from researchers in the College of Pharmacy at The University of Texas at Austin in the journal Science provide new findings in alcohol use disorder (AUD) research. The article, “Compelled to drink: Why some cannot stop,” considers recent findings by researchers Siciliano et al. that discovered individual differences in the activity of neurons in a frontal cortex to brain stem circuit that predicts the later escalation of alcohol drinking to compulsive intake in a mouse model. “These researchers not only defined a new brain circuit involved in compulsive drinking, but showed individual differences at the level of electrical activity in the neurons that comprise this circuit,” Nixon said. “The individual differences in electrical activity predicted which mice would go on to drink compulsively after a binge-like drinking episode despite drinking the same amount of alcohol during that episode.”

The research group previously found that this circuit is important for responses to aversive events, and they have now asked why aversive outcomes don’t deter everyone from drinking alcohol. These new findings point to a neurological explanation for why only some mice continue to drink alcohol even when it comes with negative consequences. “They found these differences in circuit activity before mice developed compulsive drinking behavior,” Mangieri said. “In other words, some mice had a biological predisposition that made them susceptible to developing alcohol drinking behaviors that are similar to humans with AUD.”

The researchers said the work has important implications. It has potential as a biomarker of propensity to develop severe AUD based on electrical activity. Also, the discovery of this circuit’s role in compulsive drinking suggests that there may be novel pharmacological targets that could be identified and developed for the treatment of AUDs.

(Source: https://news.utexas.edu/)

As cases of coronavirus infection proliferate around the world and governments take extraordinary measures to limit the spread, there is still a lot of confusion about what exactly the virus does to people’s bodies. The symptoms — fever, cough, shortness of breath — can signal any number of illnesses, from flu to strep to the common cold.

The virus is spread through droplets transmitted into the air from coughing or sneezing, which people nearby can take in through their nose, mouth or eyes. The viral particles in these droplets travel quickly to the back of your nasal passages and to the mucous membranes in the back of your throat, attaching to a particular receptor in cells, beginning there. Coronavirus particles have spiked proteins sticking out from their surfaces, and these spikes hook onto cell membranes, allowing the virus’s genetic material to enter the human cell. That genetic material proceeds to “hijack the metabolism of the cell and say, in effect, ‘Don’t do your usual job. Your job now is to help me multiply and make the virus,’” said Dr. William Schaffner.

As copies of the virus multiply, they burst out and infect neighboring cells. The virus then “crawls progressively down the bronchial tubes,” Dr. Schaffner said. When the virus reaches the lungs, their mucous membranes become inflamed. That can damage the alveoli or lung sacs and they have to work harder to carry out their function of supplying oxygen to the blood that circulates throughout our body and removing carbon dioxide from the blood so that it can be exhaled. The swelling and the impaired flow of oxygen can cause those areas in the lungs to fill with fluid, pus and dead cells. Pneumonia, an infection in the lung, can occur.

(Source: https://www.nytimes.com/)

In all the debate about conservation of natural landscapes, we must not forget that the 19th century also saw the development of interest in the cultural past. Although archaeology was around 100 years old at this point, at least in the Old World, it was largely an exercise in treasure hunting - digging up the treasures of the past as curiosities for museums or for the private collections of those who funded the dig.

Changes in attitudes and law throughout the 19th century meant that monuments and artefacts were becoming part of the study of the past, no longer merely trinkets and curiosities, but indicators of a culture’s development and identity. Modern archaeology would not arrive until the 20th century and the concept of an archaeological landscape is younger still. The first laws to protect and conserve cultural heritage came into place in the late 19th and early 20th centuries in the developed countries. In the US, the first such law was the Antiquities Act in 1906 which gave the office of president the power to set aside areas of land as protected cultural assets, known as “National Monuments”. This law was in place until 1979 when it was replaced with the Archaeological Resources Protection Act but several other laws came into place before then that required archaeologists to label and give proper contexts to monuments and artefacts.

There was also a global movement to protect by law and provide resources and funds for monuments that were nationally important, but also those deemed significant to human civilization as a whole. Founded in 1945, has many responsibilities, one of the most important as far as archaeological conservation is concerned is the World Heritage List. The list began in 1975 as a recognition of globally important sites. The first 12 added on that first day included: L’Anse Aux Meadows in Canada, The Galapagos Islands, Quito in Ecuador, Krakow, and Mesa Verde National Park in the US. Today, there are over 1,000 cultural monuments and natural landscapes on this list.

In the 21st century, it is common for countries to have laws in place to protect monuments, sites, and landscapes of cultural or historical importance and government-established charities or government departments assigned to their management, upkeep or conservation. The threats to them and their conservation go beyond the issues of the 19th century (plunder and theft).

(Source: https://www.environmentalscience.org/)

Without regular supplies of some hormones our capacity to behave would be seriously impaired; without others we would soon die. Tiny amounts of some hormones can modify our moods and our action, our inclination to eat or drink, our aggressiveness or submissiveness, and our reproductive and parental behavior. And hormones do more than influence adult behavior; early in life they help to determine the development of bodily form and may even determine an individual’s behavioral capacities. Later in life the changing outputs of some endocrine glands and the body’s changing sensitivity to some hormones are essential aspects of the phenomena of aging.

Communication within the body and the consequent integration of behavior were considered the exclusive province of the nervous system up to the beginning of the present century. The emergence of endocrinology as a separate discipline can probably be traced to the experiments of Bayliss and Starling on the hormone secretion. This substance is secreted from cells in the intestinal walls when food enters the stomach; it travels through the bloodstream and stimulates the pancreas to liberate pancreatic juice, which aids in digestion. By showing that special cells secrete chemical agents that are conveyed by the bloodstream and regulate distant target organs or tissues, Bayliss and Starling demonstrated that chemical integration can occur without participation of the nervous system.

William Bayliss and Ernest Henry Starling, two British physiologists, discovered and introduced the word hormone. In 1979, The Bayliss and Starling Society was founded as a forum for research scientists with specific interest in the chemistry, physiology and function of central and autonomic peptides. The Society also offered the travelling fellowship award for members who wanted to attend national and international academic conferences. Sometimes, the Society help schools to organize science fairs for secondary students and give them incentives to fall for related subjects.

The term “hormone” was first used with reference to secretion. Starling derived the term from the Greek hormone, meaning “to excited or set in motion.” The term “endocrine” was introduced shortly thereafter, “Endocrine” is used to refer to glands that secrete products into the bloodstream. The term “endocrine” contrasts with “exocrine” which is applied to glands that secrete their products through ducts to the site of action. Examples of exocrine glands are the tear glands, the sweat glands, and the pancreas, which secretes pancreatic juice through a duct into intestine. Exocrine glands are also called duct glands, while endocrine glands are called ductless.

(https://www.passeidireto.com)

An individual’s personality is the complex of mental characteristics that makes them unique from other people. It includes all of the patterns of thought and emotions that cause us to do and say things in particular ways. At a basic level, personality is expressed through our temperament or emotional tone. However, personality also colors our values, beliefs, and expectations. There are many potential factors that are involved in shaping a personality. These factors are usually seen as coming from heredity and the environment. Research by psychologists over the last several decades has increasingly pointed to hereditary factors being more important, especially for basic personality traits such as emotional tone. However, the acquisition of values, beliefs, and expectations seem to be due more to socialization and unique experiences, especially during childhood.

Some hereditary factors that contribute to personality development do so as a result of interactions with the particular social environment in which people live. For instance, your genetically inherited physical and mental capabilities have an impact on how others see you and, subsequently, how you see yourself. Likewise, your health and physical appearance are likely to be very important in your personality development. You may be frail or robust. You may have a learning disability. You may be slender in a culture that considers obesity attractive or vice versa. These largely hereditary factors are likely to cause you to feel that you are nice-looking, ugly, or just adequate. Likewise, skin color, gender, and sexual orientation are likely to have a major impact on how you perceive yourself. Whether you are accepted by others as being normal or abnormal can lead you to think and act in a socially acceptable or marginal and even deviant way.

There are many potential environmental influences that help to shape personality. Child rearing practices are especially critical. In the dominant culture of North America, children are usually raised in ways that encourage them to become self-reliant and independent. Children are often allowed to act somewhat like equals to their parents. Children are given allowances and small jobs around the house to teach them how to be responsible for themselves. In contrast, children in China are usually encouraged to think and act as a member of their family and to suppress their own wishes when they are in conflict with the needs of the family. Independence and self-reliance are viewed as an indication of family failure and are discouraged.

(https://www.researchgate.net)

Rogue waves are extremely large waves that are more than double the average height of most waves. According to mathematical calculations and various personal accounts, rogue waves can reach remarkable heights. They appear unexpectedly in calm waters and can do major damage, even to large ships. Unlike tsunamis, which are practically undetectable in deep water, rogue waves only occur far out at sea. Stories about rogue waves have circulated amongst sailors for centuries, but it was not until recently that scientists confirmed they actually exist. What they still are not sure of, however, is what causes them.

Some instances of rogue waves have been explained by the interactions of normal wave patterns with ocean currents. Scientists believe that it is possible for waves to reach the heights described when they come into contact with strong ocean currents. The wave heights increase significantly when a normal wave reaches a current head on. In other words, the wave is built up by the power of the current. This explanation was first proposed after scientists observed a high incidence of rogue waves in the ocean surrounding the southern tip of Africa. In fact, since 1990, at least twenty ships have encountered the waves, which reportedly reached up to 190 feet. The waves are thought to be caused by wave interactions with the strong Agulhas Current, which runs southbound along the east coast of the continent.

Ocean currents may be responsible for rogue waves in some parts of the world, but scientists have confirmed their existence even in areas that are not affected by strong currents. In those cases, scientists think that the waves are caused by wave reinforcement. Wave reinforcement is when two or more waves join together to form one massive wave. When the waves are joined, each height is added to the others. For example, if a ten-foot wave comes into contact with a fifteen-foot wave, the resulting wave will be twenty-five feet tall. According to some evidence, it is possible that many waves can join together, which would create rogue waves. Scientists still do not understand which circumstances cause wave reinforcement, but many propose that the reason rogue waves appear suddenly is because they are formed by multiple smaller waves randomly.

(https://en.wikipedia.org/wiki/Rogue_wave)

Until the twentieth century cigarettes were not an important threat to public health. Men used tobacco mainly in the form of cigars. They chewed tobacco, piped tobacco, and snuffed. Most women did not use tobacco at all.

The cigarette industry began in 1870s with the development of the cigarette manufacturing machine. This made it possible to produce great numbers of cigarettes very quickly, and it reduced the price.

Today cigarette smoking is a widespread habit. About forty-three percent of the adult men and thirty-one percent of the adult women in the United States smoke cigarettes regularly. It is encouraging to note, however, that millions of people have quits smoking. Seventy-five percent of the male population and forty-six percent of the female population have smoked cigarettes for some time during their lives, but twenty-six percent of these men and eleven percent of women have stopped smoking. The number of persons who have given up smoking is increasing. Men as a group smoke more than women. Among both men and women the age group with the highest proportion of smokers is the age group 24-44.

Income, education, and occupation all play a part in determining a person’s smoking habit. City people smoke more than people living on farms. Well-educated men with high incomes are less likely to smoke cigarettes than men with fewer years of schooling and lower incomes. On the other hand, if a well-educated man with a higher income smokes, he’s likely to smoke more packs of cigarettes per day.

The situation is somewhat different for women. There are slightly more smokers among women with higher family incomes and higher education than among the lower income and lower educational groups. These more highly educated women tend to smoke more heavily.

Among teenagers the picture is similar. There are fewer teenager smokers from upper-income, well-educated families, and also fewer from families living in farm areas. High school students who are preparing for college are less likely to smoke than those who don’t plan to continue their education after high school. Children are most likely to start smoking if one or both of their parents smoke.

(http://www.koolearn.com/shiti/list-2-3-122317-356.html)